NFL Picks: 2021 Week 16

By Kevin Schroeder
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Updated: December 23, 2021

Last week: 11-5 straight up, 12-4 against the spread, 3-1 best bets, 0-1 lock of the week
Season: 132-91-1 straight up, 113-110-1 against the spread, 23-29 best bets, 5-10 lock of the week

Last week:

Was chaotic. Didn’t make a new chart.

Lines for this week’s NFL games come from FanDuel, except for lines marked with an asterisk, which are consensus lines because the game is not on the board at FanDuel at the time of writing. Bold indicates a best bet. Bold and italic indicates the lock of the week.

Away	Line	Home	Straight Up	Against the Spread
San Francisco	-3.5	Tennessee	San Francisco	San Francisco
Cleveland	+7.5	Green Bay	Green Bay	Cleveland
Indianapolis	+1.5	Arizona	Indianapolis	Indianapolis
Tampa Bay	-10	Carolina	Tampa Bay	Tampa Bay
New York Giants	+10	Philadelphia	Philadelphia	Philadelphia
Los Angeles Chargers	-10	Houston	Los Angeles Chargers	Los Angeles Chargers
Detroit	+6	Atlanta	Atlanta	Detroit
Baltimore	+3.5	Cincinnati	Cincinnati	Cincinnati
Los Angeles Rams	-3.5	Minnesota	Los Angeles Rams	Minnesota
Jacksonville	-1	New York Jets	New York Jets	New York Jets
Buffalo	+2	New England	Buffalo	Buffalo
Chicago	+6.5	Seattle	Seattle	Chicago
Pittsburgh	+7.5	Kansas City	Kansas City	Kansas City
Denver	-1	Las Vegas	Denver	Denver
Washington	+10	Dallas	Dallas	Dallas
Miami	-2.5	New Orleans	Miami	Miami

Only 2 best bets this week. Thought about Dallas -10, but that was too many points for me to make a best bet. That is the game I like 3rd-best this week, though. New Orleans is starting Ian Book this week, so I love Miami -2.5. If the Saints actually win that game, it’s time to start the Payton vs. Belichick debate.

If you’re on mobile and the chart isn’t displaying correctly, here’s an image. Click to embiggen.