NFL Picks: 2021 Week 1

By Kevin Schroeder
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Updated: September 9, 2021

The Dallas Cowboys paid someone to figure out the logistics of transporting watermelons. That’s the joke. [Photo credit: Rich Eisen Show on Twitter]

Last season: 167-86-1 straight up, 119-127-7 against the spread, 26-29-3 best bets, 9-7-1 lock of the week

Lines for this week’s NFL games come from FanDuel, except for lines marked with an asterisk, which are consensus lines because the game is not on the board at FanDuel at the time of writing. Bold indicates a best bet. Bold and italic indicates the lock of the week.

Away	Line	Home	Straight Up	Against the Spread
Dallas	+8.5	Tampa Bay	Tampa Bay	Tampa Bay
Pittsburgh	+6.5	Buffalo	Buffalo	Buffalo
New York Jets	+4.5	Carolina	New York Jets	New York Jets
Jacksonville	-3	Houston	Jacksonville	Jacksonville
Arizona	+3	Tennessee	Tennessee	Tennessee
Los Angeles Chargers	-1	Washington	Los Angeles Chargers	Los Angeles Chargers
Philadelphia	+3	Atlanta	Atlanta	Philadelphia
Seattle	-3	Indianapolis	Seattle	Seattle
Minnesota	-3	Cincinnati	Minnesota	Minnesota
San Francisco	-7.5	Detroit	San Francisco	San Francisco
Cleveland	+6.5	Kansas City	Kansas City	Cleveland
Miami	+3	New England	New England	New England
Denver	-2.5	New York Giants	Denver	Denver
Green Bay	-4	New Orleans	New Orleans	New Orleans
Chicago	+7.5	Los Angeles Rams	Los Angeles Rams	Chicago
Baltimore	-4.5	Las Vegas	Baltimore	Baltimore