NFL Picks: 2021 Week 5

By Kevin Schroeder
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Updated: October 7, 2021

Last week: 10-6 straight up, 7-9 against the spread, 2-1 best bets, 0-1 lock of the week
Season: 36-28 straight up, 33-31 against the spread, 8-6 best bets, 1-3 lock of the week

Last week:

Lines for this week’s NFL games come from FanDuel, except for lines marked with an asterisk, which are consensus lines because the game is not on the board at FanDuel at the time of writing. Bold indicates a best bet. Bold and italic indicates the lock of the week.

Away	Line	Home	Straight Up	Against the Spread
Los Angeles Rams	-2.5	Seattle	Los Angeles Rams	Los Angeles Rams
New York Jets	+3	Atlanta	New York Jets	New York Jets
Miami	+10	Tampa Bay	Tampa Bay	Tampa Bay
Philadelphia	+3	Carolina	Carolina	Carolina
New Orleans	-2.5	Washington	New Orleans	New Orleans
Tennessee	-4.5	Jacksonville	Tennessee	Tennessee
Detroit	+10	Minnesota	Minnesota	Detroit
Denver	+1.5	Pittsburgh	Denver	Denver
Green Bay	-3	Cincinnati	Green Bay	Green Bay
New England	-8.5	Houston	New England	New England
Chicago	+5.5	Las Vegas	Las Vegas	Chicago
Cleveland	+2	Los Angeles Chargers	Los Angeles Chargers	Los Angeles Chargers
New York Giants	+7	Dallas	Dallas	Dallas
San Francisco	+4.5	Arizona	Arizona	Arizona
Buffalo	+3	Kansas City	Buffalo	Buffalo
Indianapolis	+7	Baltimore	Baltimore	Baltimore