NFL Picks: 2021 Week 6

By Kevin Schroeder
- Tweet
- Pin It
Updated: October 14, 2021

Last week: 12-4 straight up, 10-5-1 against the spread, 2-2 best bets, 1-0 lock of the week
Season: 48-32 straight up, 43-36-1 against the spread, 10-8 best bets, 2-3 lock of the week

Last week:

Lines for this week’s NFL games come from FanDuel, except for lines marked with an asterisk, which are consensus lines because the game is not on the board at FanDuel at the time of writing. Bold indicates a best bet. Bold and italic indicates the lock of the week.

Away	Line	Home	Straight Up	Against the Spread
Tampa Bay	-6.5	Philadelphia	Tampa Bay	Tampa Bay
Miami	-3	Jacksonville	Miami	Miami
Houston	+10	Indianapolis	Indianapolis	Houston
Green Bay	-4.5	Chicago	Chicago	Chicago
Kansas City	-6.5	Washington	Kansas City	Kansas City
Minnesota	-1.5	Carolina	Carolina	Carolina
Los Angeles Chargers	+3	Baltimore	Los Angeles Chargers	Los Angeles Chargers
Cincinnati	-3.5	Detroit	Cincinnati	Cincinnati
Los Angeles Rams	-9.5	New York Giants	Los Angeles Rams	Los Angeles Rams
Arizona	+3	Cleveland	Arizona	Arizona
Las Vegas	+3.5	Denver	Denver	Las Vegas
Dallas	-3.5	New England	Dallas	Dallas
Seattle	+5.5	Pittsburgh	Pittsburgh	Pittsburgh
Buffalo	-5.5	Tennessee	Buffalo	Buffalo